PROCESS FOR PREPARING CARBOXYALKENAMIDO-CEPHALOSPORINS

摘要

Cephalosporins (I)[X=bond, alkylene, oxaalkylene, thiaalkylene; X1=O, S, SO; R, R5=H, cation, ester gp.; R1=H, halogen; R2=aryl, heterocyclic; R3=H, OMe; R4=H, usual 3-substituent are prepd. Thus, (II) (R=CMe3, R5=CHPh2, R6=CO2CH2Ph, R7=Br, n=1) is treated with NaSCH2CN, followed by reduction and ester cleavage with AlCl3-PhoMe to give (II)(R, R5, R6=H, R7=SCH2CN, n=o).