发明名称 |
PROBE CONTAINING A MODIFIED NUCLEIC ACID RECOGNIZABLE BY SPECIFIC ANTIBODIES AND THE USE TO DETECT AND CHARACTERIZE A HOMOLOGOUS DNA SEQUENCE |
摘要 |
1. Kit for the detection of predetermined nucleotide sequences or more generally particular DNAs in a biological sample liable to contain it, characterized in that it comprises : - a probe containing a sequence complementary to the nucleic acid which is sought, said probe comprising at least one 7-iodo-N-acetylaminofluorene group (AAIF group) covalently fixed at one at least of its bases and - antibodies which can react with either N-2-(guanosine-8-yl)-acetylaminofluorene or with antibodies previously prepared against a nucleotidic acid sequence modified by a N-2-acetylaminofluorene group (antibodies AAF). |
申请公布号 |
DE3474305(D1) |
申请公布日期 |
1988.11.03 |
申请号 |
DE19843474305 |
申请日期 |
1984.12.28 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);INSTITUT PASTEUR |
发明人 |
TCHEN, PAUL;FUCHS, ROBERT;LENG, MARC |
分类号 |
G01N33/53;C07H21/02;C07H21/04;C12N15/00;C12N15/09;C12Q1/68;G01N33/531;G01N33/532;(IPC1-7):C07H21/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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