Isoquinolinesulfonamide derivatives and process for the preparation thereof.

摘要

This invention relates to novel isoquinolinesulfonamide derivates of Formula (I):
wherein A is a C_0-10 alkylene group or a C_0-10 alkylene group having a C_1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R₁ and R₂ each is a hydrogen atom; or R₁ and R₂ are linked directly to form an ethylene group unsubstituted or substituted with a C_1-4 alkyl group;

R₃ and R₄ each is a hydrogen atom, a C_1-6 alkyl group or linked directly to form a C₂-₆ alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a precess for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.