| 摘要 |
NEW MATERIAL:2,4,5-Trifluoro-3-hydroxybenzoic acid expressed by formula I and salt thereof. USE:Useful as a synthetic intermediate for quinolonecarboxylic acid based antimicrobial agents. PREPARATION:A compound expressed by formula II (R is H or organic group capable of forming hydroxyl group by hydrolysis) is treated in water or an aqueous solvent at 80-230 deg.C, preferably 100-190 deg.C normally for 0.5-20hr under autogenous pressure to afford the aimed compound expressed by formula I. Furthermore, the amount of the solvent is preferably within the range of 3-100 times based on the raw material compound expressed by formula II. A mixture of methanol, ethanol, dioxane, etc., with water is cited as specific examples of the aqueous solvent. The content of the water is preferably >=10%. The reaction may be carried out in the presence of an inert gas, such as nitrogen or argon.
|
