发明名称 |
PROCESS FOR PRODUCING N-/4-<2-(PYRIDO/2,3-D/-PYRIMIDIN-6-YL)-ALKYL>-BENZOYL/-L-GLUTAMINIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p>2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]-benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8- tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8,-tetrahydropyrido[2-3-d]pyrimidin-6 -yl)-ethyl]benzoyl)-L-glutamic acid.</p> |
申请公布号 |
HU196202(B) |
申请公布日期 |
1988.10.28 |
申请号 |
HU19860002011 |
申请日期 |
1986.02.24 |
申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY,US |
发明人 |
TAYLOR,EDWARD,US;HARRINGTON,PETER,US;BEARDSLEY,GEORG P.,US;FLETCHER,STEPHEN R.,GB |
分类号 |
A61K31/495;A61K31/195;A61K31/505;A61K31/519;A61P35/00;C07D471/00;C07D471/04;(IPC1-7):C07D471/04;A61K31/395 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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