| 摘要 |
<p>There are disclosed compounds of the formula <CHEM> where m is 1 or 2; n is 1 or 2; P is 0 or 1; each R is independently hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, nitro, amino, loweralkylamino, loweralkylcarbonylamino, cyano, formyl, loweralkoxycarbonyl, loweralkylthio or loweralkoxycarbonylloweralkylthio; each R1 is independently hydrogen, loweralkyl, loweralkenyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, arylcarbonyl, halogen, arylloweralkenyl, arylloweralkyl, heteroarylloweralkenyl, heteroarylloweralkyl, cyanoloweralkenyl, cyanoloweralkyl, methoxyloweralkenyl, methoxyloweralkyl, loweralkoxycarbonylloweralkenyl, loweralkoxycarbonylloweralkyl, cycloalkylloweralkenyl or cycloalkylloweralkyl, the term heteroaryl signifying a group of the formula <CHEM> where W is O, S, NH or CH=N, cyano, -CH(OH)R4, -C(OH)R4R5 or -CH2OR5, R4 being hydrogen, loweralkyl, arylloweralkyl or aryl and R5 being loweralkyl, arylloweralkyl or aryl; each R2 is independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkoxycarbonylloweralkyl, loweralkylaminocarbonylloweralkyl, aminocarbonylloweralkyl, arylloweralkyl, phenyl, nitrophenyl, cyanophenyl, trifluoromethylphenyl, aminophenyl, loweralkanoylaminophenyl, loweralkoxycarbonyl, arylloweralkoxycarbonyl, aryloxycarbonyl, loweralkylaminocarbonyl, arylloweralkylaminocarbonyl, arylaminocarbonyl, alkanoyl, arylloweralkanoyl, aroyl, alkenoyl, alkynoyl or -R6-NR min R sec where R6 is loweralkylene, loweralkenylene or loweralkynylene and R min and R sec are each independently loweralkyl or alternatively the group -NR min R sec as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-loweralkyl-1-piperazinyl or 4-aryl-1-piperazinyl; and R3 is hydrogen, nitro, amino, halogen, loweralkanoylamino, arylloweralkanoylamino, aroylamino, alkylamino, arylloweralkylamino or loweralkyl and a process for their preparation. The compounds are useful for enhancing memory and also as analgesic and antidepressant agents.</p> |
