发明名称 |
A method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine. |
摘要 |
<p>There is disclosed a method for culturing Bordetella Pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amount at low cost. From the antigen, there can be obtained a stable and effective pertussis toxoid to be used for a pertussis vaccine. There is also disclosed a vaccine comprising the pertussis toxoid as an active ingredient and a gelatin and/or gelatin derivatives as a stabilizing agent. The present vaccine is extremely stable and can be stored for a prolonged period of time.</p> |
申请公布号 |
EP0287732(A1) |
申请公布日期 |
1988.10.26 |
申请号 |
EP19870306165 |
申请日期 |
1987.07.13 |
申请人 |
THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY |
发明人 |
CHAZONO, MASASHI;YOSHIDA, IWAO;KONOBE, TAKEO;OSAME, JUICHIRO;TAKAKU, KEISUKE |
分类号 |
A61K39/00;A61K39/10;C07K14/235;C12N1/20;C12N1/22;(IPC1-7):A61K39/10 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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