Production of Peptide.

摘要

A peptide having hepatitis B virus surface antigenicity such as S, M or L protein can be excreted outside a eukaryotic cell carrying a recombinant DNA in which a DNA coding for a signal peptide which functions in a eukaryotic cell is bound to the 5'-terminal of a DNA coding for the peptide having hepatitis B virus surface antigenicity by cultivating the eukaryotic cell carrying the recombinant DNA. In particular, the L protein is not only excreted outside the cell but also accumulated within the cell. The produced peptide having hepatitis B surface antigenicity can be used as vaccine for prevention of hepatitis B virus infection and as an agent for a diagnostic kit.