发明名称 Analogs of (1,7-di-alanine, des-19-leucine) calcitonine.
摘要 <p>New hypocalcaemic peptides are disclosed of the formula &lt;IMAGE&gt; wherein X represents H for the replacement of the N alpha amino group or acyl groups for the acylation of the N alpha amino group. The acyl groups are carboxylic acids expecially formic, acetic, propionic, buteric, valeric, hexanoic, heptanoic, octanoic, and nonanoic acids or their respective isomers, L-lactic acid and the half amides of malonic, succinic, glutaric and adipic acids. Y is L-valine, glycine, L-methionine, L-alanine, L-leucine or L-isoleucine.</p>
申请公布号 EP0288058(A2) 申请公布日期 1988.10.26
申请号 EP19880106411 申请日期 1988.04.21
申请人 RORER INTERNATIONAL (OVERSEAS) INC. 发明人 ORLOWSKI, RONALD C.;SEYLER, JAY K.;GEEVER, JAMES E.;FLANIGAN, EVERETT
分类号 C07K14/575;A61K38/00;C07K14/585 主分类号 C07K14/575
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