Isoquinoline derivatives.

摘要

Isoquinoline derivatives represented by the formula (I) <CHEM> wherein R<1> is selected from the group consisting of a hydrogen atom, a chlorine atom and a hydroxyl group; R<2> is selected from the group consisting of an alkyl group having 1 to 8 carbon atoms and a benzyl group, or directly bonded with R<3> to form Z; R<3> is selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 8 carbon atoms, or directly bonded with R<2> to form Z; said Z being selected from the group consisting of an unsubstituted ethylene group, an ethylene group substituted with an alkyl group having 1 to 8 carbon atoms, an unsubstituted trimethylene group, and a trimethylene group substituted with an alkyl group having 1 to 8 carbon atoms; provided that where R<2> and R<3> are not directly bonded with each other, R<1> is a hydrogen atom, and where R<2> and R<3> are directly bonded with each other to form Z, R<1> is selected from the group consisting of a hydrogen atom, a chlorine atom and a hydroxyl group; R<4> and R<5> are independently selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 6 carbon atoms which is unsubstituted or substituted with a phenyl group, and a phenyl group, or R<4> and R<5> are each alkylene groups having 1 to 5 carbon atoms and bonded with each other directly or through an oxygen atom to form a heterocyclic ring in cooperation with the adjacent nitrogen atom, the total number of carbon atoms in the two alkylene groups not exceeding 6; and A is an alkylene group having 1 to 5 carbon atoms which is unsubstituted or substituted with an alkyl group having 1 to 8 carbon atoms; or a pharmacologically acceptable acid salt thereof. These compounds have an excellent relaxation action on blood vessels, particularly coronary arterys, and on bronchial tubes. Accordingly, the compounds can be advantageously utilized as drugs for prevention and treatment of angina, myocardial infarction, cardiovascular thrombosis, cerebrovascular thrombosis, hypertonia, asthma and other various circulatory and respiratory organ diseases.