| 摘要 |
A (fused) benz(thio)amide of the formula: <IMAGE> (I) wherein B represents (i) a carbocyclic ring of from 4 to 8 members being unreplaced or replaced one, two or three of optional carbon atom(s) by oxygen, nitrogen and/or sulphur atom(s) or (ii) a divalent group of the formula: <IMAGE> R1 represents a group of formula: <IMAGE> (i) <IMAGE> (ii) <IMAGE> (iii) (iv) a straight or branched alkyl, alkenyl, or alkynyl of from 1 to 20 carbon atoms, R4 represents (i) when B represents a closed ring, a group of the formula: U(CH2)nCOOR8 <IMAGE> (CH2)pCOOR8 or <IMAGE> (ii) when B does not represent a ring, a group of formula: (CH2)pCOOR8 or <IMAGE> with the proviso that compounds of formula: <IMAGE> wherein A' is a vinylene or an ethylene group optionally substituted by straight or branched alkyl groups of from 1 to 4 carbon atom(s); R4' is -(CH2)n-COOR8 - and R1' is (i) a group of the formula: <IMAGE> or (ii) a group of the formula: <IMAGE> are excluded, wherein A, R2, R3, R5, R6, R7, R8, U, n, m, p, q, R5', and R6' are defined as in the above specification, possessing antagonistic activity on leukotrienes (SRS), inhibitory activity on 5 alpha -reductase, on phospholipase and on aldose reductase and being useful for the prevention and/or treatment of diseases induced by leukotrienes, 5 alpha -reductase, phospholipase and aldose reductase in mammals, especially in human beings.
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