| 摘要 |
<p>HA276 Dioxolenylmethyl Ester Prodrugs Of Phosphinic Acid ACE Inhibitors Angiotensin converted enzyme inhibitor activity is exhibited by compounds having the formula and salts thereof wherein R1 is hydrogen, aryl, or heteroaryl: R2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino; R3 is hydrogen, alkyl, or aminoalkyl; R4 and R5 are the same or different and each is hydrogen, alkyl, halogen, aryl, arylalkyl, hydroxy, alkoxy, alkylthio, aryloxy, arylthio, or cycloalkyl, or R4 and R5 taken together are oxo, ethylenedithio or propylenedithio; one of R6 and R7 is and the other is hydrogen, alkyl or arylalkyl; HA276 R8 is hydrogen, alkl or aryl; R9 is hydrogen or alkyl, n is 0 or an integer of 1 to 8; m is 0 or 1; and A is -(CH2)p- wherein p is 0 or 1, -NH-, or -O-.</p> |
