ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF 2-OXABICYCLO-(3,3,0)OCTANDERIVATER

摘要

Disclosed are new heterocyclic compounds, medicaments containing them (for oral or parenteral administration) and processes for the preparation and use of these heterocyclic compounds and medicaments. The new compounds which particularly act as inhibitors of blood platelet aggregation and as blood pressure lowering agents correspond to the general formula (I) wherein R1 is hydrogen, a cation or the residue of an alcohol, R2 represents hydrogen or methyl, A is a member of the group consisting of the radicals -CH2-CH2-, (trans)-CH=CH- and -C 3BOND C-, and wherein B represents an alkyl or a cycloalkyl radical. In these compounds the phenyl radical may be arranged with respect to the double bond in the E- and/or in the Z-configuration and at the carbon atom bearing the group R2 (and others) may exist RS- or S-configuration. The compounds of formula I are prepared in a manner known per se starting from derivatives of 3 alpha ,5 alpha -dihydroxycyclopentane-1 alpha -acetaldehyde gamma -lactol substituted accordingly and phosphonium salts of the formula wherein R6 represents hydrogen or alkyl and wherein Hal is chlorine, bromine or iodine.