| 摘要 |
<p>Various disorders of the human skin, particularly facial skin, of elderly individuals, may be treated with low doses of 13-cis-retinoic acid by oral administration in amounts which are non-toxic and non-teratogenic. The disorders are those which appear in the elderly and are complicated by excessive sun exposure (photoaging), including sebaceous gland hyperplasia, follicular Demodex infestation, bacterial and fungi-induced folliculitis, rosacea-like and seborrheic-like dermatoses and dandruff-like scalp conditions. The treatment is effective at doses of as low as 1-5 mg daily or every other day, and is preferably used with women beyond childbearing potential, and males over about 50 years of age. The treatment also retards and reverses hyperkeratosis, epidermal atrophy, and other skin changes of the elderly.</p> |
