BIOLOGICALLY ACTIVE TRIPEPTIDE AND TETRAPEPTIDE ALKYLAMIDES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

The invention relates to novel biologically active tripeptide and tetrapeptide alkylamides of the general formula (I): (I) wherein R1 is an alkyl radical with 1 to 5 carbon atoms, A is a peptidically bound alanine or proline rest, B is a peptidically bound glycine, alanine or proline rest, n is an integer of 1 or 2 and R2 is an alkylcarbonylamino group with 2 to 12 carbon atoms, an alkenyl radical with 6 to 12 carbon atoms or a benzyloxycarbonylamino group. These compounds show a remarkable inhibitory activity towards the pancreatic and leucocytal elastase and are expected to find use in the treatment of acute pancreatitis, chronical obstructive pulmonary disease (pulmonary emphysema) and certain forms of arthrites. The invention also relates to processes for the preparation of the title compounds and to pharmaceutical compositions containing the same.