| 摘要 |
The pH independent and controlled-release tablets comprise a mixt. of dipyridamole (I) or its salts, >=18 acid equivs. of >=1 nontoxic acid/ mol (I) and a sufficient amt. of disintegrant to allow 90% dissoln. of (I) in the gastrointestinal pH range of 1-7. Thus, a mixt. of (I) 0.3, fumaric acid 0.63, PVP 0.07, lactose 0.37, and Na starch glycolate 0.11kg was wet granulated with iso-PrOH, screened through a 18 mesh-sieve and dried at -40↿C. The dried granule, 1.012 kg Mg stearate and 0.06kg colloidal SiO2 were mixed and compressed into 50mg tablets. The tablets showed 100% dissoln. in < 1hr at pH.s 1.2, 4.0, 6.0 and H2O. |
