| 摘要 |
The title compds. of formula are new. R1=H or lower alkyl, R2 and R3=H, halogen, OH or lower alkoxy independently, Ar=pyridyl, B=carboxy, lower alkoxy carbonyl. Reflux a soln. of 1-(5-carboxy, lower alkoxy carbonyl. Reflux a soln. of 1-(5carbamoylpentyl)-5- chloro-3-methyl-2-(3-pyridyl)-indole 50mg/6N HCl 1ml for 3 hr, cool to ppte., conc. by drying, basify with satd. NaHCO3 soln., wash with ether, neutralize with 2N HCl until pH6-7 to give 1-(5-carboxypentyl) -5-chloro-3-methyl-2-(3-pyridyl)indole. (I) are used as inhibitor to thromoxane synthesis enzyme in the mammal.
|
