Ethanolamine derivates, processes for their preparation and pharmaceutical compositions containing them.

摘要

This invention relates to compounds of the general formula (I) <CHEM> and physiologically acceptable salts and solvates thereof where Ar represents <CHEM> where R<3> is a bond or a straight or branched C1-2alkylene group, R<4> is a hydroxy group or a group R<5>NH- where R<5> represents a group CH3SO2-, HCO- or NH2CO-, <CHEM> <CHEM> where R<6> is a chlorine atom or the group F3C-, <CHEM> k represents an integer from 1 to 8, m represents zero or an integer from 2 to 7 and n represents an integer from 2 to 7 with the proviso that the sum total of k, m and n is 4 to 12; R<1> and R<2> each represents a hydrogen atom or a methyl or ethyl group with the proviso that the sum total of carbon atoms in R<1> and R<2> is not more than 2; R<3><0> represents hydrogen or C1-2alkyl; X represents an oxygen or sulphur atom; and Y and Q may each represent a bond or an oxygen or sulphur atom with the provisos that at least one of Y and Q represents an oxygen or sulphur atom and when Y is a bond m is zero, or when Y represents an oxygen or sulphur atom m is an integer from 2 to 7; P represents a phenyl group otionally substituted by one or more substituents selected from halogen atoms, or the groups C1-3alkyl, C1-3alkoxy, hydroxy, -CH2OH-, -(CH2)2OH, -CO2H, -CO2CH3, -CO2(CH2)2CH3, -R<7>, COR<7>, -NHCOR<8> and -NR<9>SO2R<1><0>; where R<7> represents an amino, aminoC1-3alkyl, aminoC1-3dialkyl, pyrrolidino, piperidino, hexamethyleneimino, piperazino, N-methylpiperazino or morpholino group; R<8> represents a hydrogen atom or a C1-4alkyl, C1-4alkoxy, phenyl or amino group; R<9> represents a hydrogen atom or a methyl group; R<1><0> represents a methyl, phenyl, amino or dimethylamino group; or P represents a pyridyl group optionally substituted by one or two substitutents selected from halogen atoms or hydroxy, C1-3alkyl and C1-3alkoxy groups. The compounds have a stimulant action at beta 2-adrenoreceptors and are useful, in particular, in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.