Cyclic imides as H1-antagonists

摘要

Polycyclic 1,3-dione imides N-alkylated with variously N-substituted alkyl- or cycloalkyl amines afford histamine H1-receptor antagonists of the formula <IMAGE> wherein R is polycyclic alkyl moiety; R1 is hydrogen or alkyl; R4 is an aromatic amine or a cycloalkyl amine containing N-substitution; R7 and R8 are hydrogen, alkyl or form a spiro cycloalkyl group.