| 摘要 |
PCT No. PCT/US85/00109 Sec. 371 Date Sep. 4, 1986 Sec. 102(e) Date Sep. 4, 1986 PCT Filed Jan. 22, 1985 PCT Pub. No. WO86/04239 PCT Pub. Date Jul. 31, 1986.A series of novel, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, containing six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention to ruminant animals (e.g. cattle and sheep) modifies their digestive fermentation processes such that the volatile fatty acids produced in the rumen contain a higher proportion of propionates rather than acetates, thereby increasing the efficiency of feed utilization in said ruminant animals. Additionally, the compounds of the invention show antibacterial activity in vitro against certain gram-positive microorganisms.
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