发明名称 |
PURIFIED PLATELET-DERIVED GROWTH FACTOR AND METHODS FOR PURIFICATION THEREOF |
摘要 |
Monoclonal antibodies specific for epitopes found on the B chain of PDGF (including v-sis, c-sis and platelet-derived forms) may be bound to columns and used for purification of rPDGF B. A solution containing a polypeptide possessing at least part of the structural conformation of rPDGF B is passed over such a column and the rPDGF B is bound to the antibody. The rPDGF B may then be eluted from the column to yield rPDGF B of greater than 95% purity as determined by SDS-PAGE. |
申请公布号 |
AU1715388(A) |
申请公布日期 |
1988.10.10 |
申请号 |
AU19880017153 |
申请日期 |
1988.03.07 |
申请人 |
AMGEN INC. |
发明人 |
MARGERY A. NICOLSON;ARLEN R. THOMASON |
分类号 |
A61K39/395;A61K38/00;A61P17/00;A61P43/00;C07K1/22;C07K14/00;C07K14/49;C07K14/52;C07K16/00;C07K16/22;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12P21/00;C12P21/02;C12P21/08;C12R1/91 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|