| 摘要 |
NEW MATERIAL:The compound of formula I [R is -SO3M (M is H, NH4 or alkali metal)] and its salt. EXAMPLE:Glycyrrhizyl pentasulfate ammonium salt. USE:An antiviral agent useful as a remedy and preventive for AIDS owing to its strong antiviral effect against retrovirus, wide active concentration range, low toxicity and high reverse transcriptase-inhibiting activity. PREPARATION:Glycyrrhizin of formula II is added with excess chlorosulfonic acid in pyridine at low temperature to effect sulfation reaction.
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