发明名称 |
PROCESS FOR THE PREPARATION OF SYMMETRIC 1,4-DIHYDROPYRIDINE-CARBOXYLIC ESTERS |
摘要 |
1. Processs for the preparation of symmetrical 1,4-dihydropyridines of the formula I see diagramm : EP0124742,P6,F1 in which R represents a phenyl radical which is optionally mono- or disubstituted by nitro and/or chlorine, and R1 represents a C1 -C4 -alkyl radical which is optionally substituted by a C1 -C4 -alkoxy group, by reaction of an ylidene compound of the formula II see diagramm : EP0124742,P6,F2 with an enamine compound of the formula III see diagramm : EP0124742,P6,F3 characterized in that the ylidene compound of the formula II is prepared by reaction of a ketocarboxylic ester of the formula IV see diagramm : EP0124742,P6,F4 with an aldehyde of the formula RCHO in a solvent, in the presence of catalytic amounts of piperidine acetate, at temperatures from - 10 degrees C and up to 100 degrees C. |
申请公布号 |
DE3473756(D1) |
申请公布日期 |
1988.10.06 |
申请号 |
DE19843473756 |
申请日期 |
1984.03.26 |
申请人 |
BAYER AG |
发明人 |
TELLER, WERNER, DR.;KOEBERNICK, WOLFGANG, DR.;HAAF, ARTHUR, DR.;NAAB, PAUL, DR.;PREISS, MICHAEL, DR. |
分类号 |
B01J31/02;C07B61/00;C07C205/56;C07D211/90 |
主分类号 |
B01J31/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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