| 摘要 |
<p>An aqueous, non-crystalline minoxidil composition for topical use. The composition contains minoxidil complexed with an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a sulfate, sulfonate, phosphate and phosphonate polar moiety. The composition may be formulated in ointment form, in an aqueous vehicle, or dispersed in a fluorochlorocarbon solvent, for spray delivery from a self-propelled spray device. The minoxidil in the composition remains in non-crystalline form for a period of at least several hours after application to the skin, thus overcoming the prior art problem of the minoxidil tending to revert to an insoluble crystalline form when prior art compositions are applied to the skin.</p> |
