SUBSTITUTED BENZAZEPINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Disclosed herein are novel 1-substituted-2,3,4,5-tetrahydro-1H-3-benzazepines of general formula (I), wherein R?1, R2, R3, R4 and R5¿ are specified substituents. R1 is preferably -X?6, -CHR7R8¿, cycloalkyl, cycloalkenyl, (II) or pyrrolyl where m is 1, R6 represents =H, phenyl, substituted phenyl, aralkyl, alkyl, cycloalkyl, haloalkyl or alkoxyalkyl, R7 represents H or alkyl preferably H, R8 represents cycloalkyl, cycloalkenyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl and R9 represents alkyl, alkoxy or alkoxyalkyl. R2 preferably represents -H and R3 -CH3, R4 is preferably halogen and R5 is preferably OH, OCO.R9 or -O(CR7)2?.OCO.R13¿ where R7 represents hydrogen, R9 is as defined above and R13 represents alkyl. The compounds of the formula (I) are indicated as being useful in the treatment of psychoses, depression and pain. Also disclosed are processes for the preparation of the novel compounds as well as pharmaceutical compositions comprising them.