Skin equivalent.

摘要

The invention relates to a skin equivalent consisting of a dermis equivalent covered by an epidermis equivalent (26). The dermis equivalent is a film consisting of a type I collagen gel containing fibroblasts. The epidermis equivalent comprises a basal membrane equivalent (5a), cells (10a) of a basal layer (6a) in a palisade arrangement and connected to the membrane equivalent (5a) by hemidesmosomes (39), cells (11a, 12a) of suprabasal layers (7a, 8a), granule cells and flattened and keratinised cells arranged in the vicinity of the free surface. <IMAGE>