发明名称 NOVEL SUBSTANCE UCY1003 AND PRODUCTION THEREOF
摘要 NEW MATERIAL:A compound expressed by the formula and having the following physico-chemical properties. Molecular formula; C28H42O4. Elementary analysis (%); C, 75.97; H, 9.56; N, 0. Molecular weight; 442 (measured by mass spectrometry). Melting point; 198.9 deg.C. Specific rotatory power; [alpha]D<25>=-60.8 deg. (C=1.0, CHCl3). Solubility; readily soluble in methanol, ethanol, chloroform and acetone, soluble in ethyl acetate, toluene and water and sparingly soluble in hexane. Properties of the substance; white needle-like crystal and neutral substance. Color reaction; positive to iodine reaction, etc. USE:An analgesic agent, hypotensive agent and antifungal agent. PREPARATION:A microorganism, belonging to the genus Penicillium and capable of producing UCY1003 [e.g. Penicillium paxilli KAC-1843 (FERM P-8581)] is cultivated at 23-28 deg.C and pH 5-7 for 1-7 days, preferably by a submerged spinner culture method.
申请公布号 JPS63239295(A) 申请公布日期 1988.10.05
申请号 JP19860294501 申请日期 1986.12.10
申请人 KYOWA HAKKO KOGYO CO LTD 发明人 NAKANO HIROFUMI;HARA MITSUNOBU;YAMASHITA YORINORI;KAWAMOTO ISAO;ANDO KATSUHIKO;SANO HIROSHI;YASUZAWA TORU;SHUDO KATSUICHI
分类号 A61K31/58;A61P9/12;A61P25/04;A61P31/04;A61P31/10;C07J71/00;C12P33/00;C12R1/80 主分类号 A61K31/58
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