| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> and R<4> are H, lower alkyl, lower alkoxy, OH, halogen, NO2 or (alkyl-substituted)amino; R<2> and R<3> are H, lower alkyl, mercapto or lower alkylthio; X is methylene or carbonyl; m and n are 0-3] or salts thereof. EXAMPLE:4-(2,6-Dimethylbenzyl)-1-(4-nitrophenyl)imidazole. USE:A medicine, cerebral function improver, antiamnesic agent and antisenile dementia agent. PREPARATION:For example, a compound expressed by formula II is reacted with p-chloronitrobenzene expressed by formula V in the presence of a base, such as K2CO3, in a solvent, such as dimethylformamide, at 20-150 deg.C to form a compound expressed by formula III, which is then reacted with H2 in the presence of a catalyst, such as Pd/C, in a solvent, such as ethyl acetate, to afford the aimed compound expressed by formula I (m is 1; R<1> is amino).
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