摘要 |
<p>Compounds of formula (I) <CHEM> in which X is H, F, Cl, Br, I, C1-4alkyl, CN, NO2, SO2NH2, COOH, CHO, C1-4alkoxy, CH2OH, CF3, SO2CH3, SO2CF3 or CO2CaH2a+1 wherein a is 1-5, or any accessible combination thereof of up to 3 substituents; R is H or C1-4alkyl; and n is 1-5; or any pharmaceutically acceptable salt or hydrate thereof, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as dopamine- beta -hydroxylase inhibitors.</p> |