发明名称 PROCESS FOR PREPARING 1,4 DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTER DERIVATIVES
摘要 The title compds. of formula (I) are new. W= -CH= or -N=; Y= -CH=CH- , -O-, -CH=N(O)p(p=0 or 1); X1, X2 and X3 are same or not, are each H, halogen, nitro; Z=Ph, tienyl, furyl; -N=A = 1pyrrolidinyl, lower alkyl, substd. piperidino by -(CH2)mOR4(R4=H, lower alkyl, m=0); R1 and R2 are same or not, are each lower alkyl; R3=benzyl, furylmethyl; n=1-5 integer. (I) show the increases of backbone and coronary hematocele in the dog, cerebrum hematocele in the rabbit and autonomous prevention of hypertension to high blood pressure rat; and these actions are maintained for a long time.
申请公布号 KR880001942(B1) 申请公布日期 1988.10.04
申请号 KR19830001047 申请日期 1983.03.16
申请人 YOSHITOMISEIYAKU CO.,LTD. 发明人 ARAKIKAZUHIRO, AOHIDEKI;IMUI, JUN;AIHARA, KENICHI
分类号 C07D211/90;C07D213/89;C07D401/04;C07D401/12;C07D405/04;C07D405/12;C07D407/12;C07D409/04;C07D409/12;C07D409/14;C07D413/12;C07D417/04;C07D417/12;C07D491/10;(IPC1-7):C07D401/12 主分类号 C07D211/90
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