摘要 |
PURPOSE:To smoothly produce the titled compound useful for the production of an alpha,beta-unsaturated carboxylic acid amide, in one step, by reacting an alkyl phosphonoacetate with amines in the presence of dimethylaminopyridine. CONSTITUTION:The objective compound of formula III (e.g. diisopropylbenzylaminocarbonylmethyl phosphonate) can be produced by reacting an alkyl phosphonoacetate of formula I (R<1> and R<4> are 1-4C alkyl; at least one of R<2> and R<3> is H and the other is H or 1-4C alkyl) (e.g. diisopropylmethoxycarbonylmethyl phosphonate) with amines of formula II (e.g. benzylamine) in the presence of 4-dimethylaminopyridine.
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