Erythromycin derivatives, process for their preparation and their pharmaceutical use.

摘要

Antibacterially active 11,12-carbonate derivatives of erythromycin 9-(optionally substituted)oxime and 9-imino compounds and their pharmaceutically acceptable ester or acid addition salt thereof: <CHEM> wherein R<1> denotes an oxime group, a substituted oxime group, or an imino group, R<3> denotes a hydrogen atom or an unsubstituted or substituted alkyl group; R<7> denotes hydrogen or methyl; one of R<8> and R<9> denotes hydrogen, hydroxy, alkoxy, alkanoyloxy, amino, substituted amino, or a group of the formula R<A>-SO2-O-, in which R<A> denotes an organic group, and the other of R<8> and R<9> denotes hydrogen, or R<8> and R<9> together denote an oxo group, an oxime group,or a substituted oxime group.