Novel glycerol derivative and anti-hypertensive agent.

摘要

A novel glycerol derivative which is effective to reduce blood pressure has the formula: <CHEM> wherein R<1> is an alkyl group having 10-22 carbon atoms, R<2> is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (-(Q) l - is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R<5>, R<6> and R<7> is hydrogen, lower alkyl, aryl or aralkyl.