| 摘要 |
Novel compounds of the formula I <IMAGE> wherein R1 is hydrogen or (C1-4)alkyl, R2 is CN, COOH, COOR5, CONH2, CONHR5, CON(R5)R6, SR5, SOR5, SO2R5, CHO, CH2OH, COR7, CH2R7', CH(OH)R5, CH2CF3, iodine, C IDENTICAL CR8, CH=CHR8, (C2-12)alkyl, NO2, NH2 or NHCOR9,wherein R5 and R6 are independently (C1-4)alkyl, R7 is (C1-4)alkyl, CF3, phenyl or phenyl(C1-5)alkyl, R7' is phenyl or phenyl(C1-5)alkyl, R8 is hydrogen, (C1-10)alkyl or phenyl and R9 is (C1-6)alkyl, R3 is (C1-5)alkyl or (C3-5)alkenyl, in which the double bond is not at the carbon atom adjacent to the nitrogen atom, and R4 is (C1-12)alkyl, (C3-7)cycloalkyl or adamantyl, or acid addition salts thereof, are useful as neuroleptic and antidepressant agents. Some of the compounds possess prolactin secretion inhibiting activity. |
