| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> represents H, lower alkyl, lower alkenyl or phenyl lower alkyl; R<2> represents formula II (X, Y and Z represent -CH= or N; R<4> and R<5> represent H, lower alkoxy, halogen atom or amino); R<3> represents H, halogen atom, nitro, amino, lower alkanoylamino, lower alkoxy, etc.; bonds at the 3- and 4-positions of carbostyril skeleton are single or double bond] and salt thereof. EXAMPLE:8-Bromo-6-[1H-imidazo-(4,5-c)-pyridin-2-yl]-3,4-dihydrocarbost yril-hy drochloride.monohydrate. USE:A cardiac, hypotensor and antiphlogistic, which has low toxicity and small side-effect. PREPARATION:A compound expressed by formula III is reacted with a com pound expressed by formula IV, as necessary, in the presence of a solvent (example; water, methanol or THF), preferably at room temperature -200 deg.C for 1-10hr.
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