| 摘要 |
<p>The invention comprises compounds of formula <FORM:1101111/C2/1> wherein R is hydrogen, methyl, chlorine or fluorine, R1 is hydrogen or methyl, =CZZ1 is one of the groups of formulae <FORM:1101111/C2/2> wherein R2 is hydrogen, hydroxy or C1- 10 aliphatic acyloxy and R5 is hydrogen or acyl, R3 is hydrogen, oxo or b -hydroxy, R4 is amino, alkylamino, alkylideneimino, aralkylideneimino, aralkylamino, acylamino, hydroxy, C2- 10 aliphatic acyloxy or C1- 4 alkoxy, X is hydrogen or fluorine, and the bonds between the 4,5 and 6,7 positions are both single or both double, or the 4,5 bond is double and the 6,7 bond is single, and their preparation by reaction of a corresponding 20-ethylenedioxy-or 17a ,20,20,21-bismethylenedioxy - 2a - cyano - pregnan - 3 - one with hydroxylamine or an acid addition salt thereof to give a compound of the invention wherein R4 is an amino group, followed if desired by (a) removal of the protecting group and/or 17-acylation, (b) conversion of the amino group R4 into a substituted amino or substituted imino group, or (c) acid hydrolysis of the amino group R4 to form a hydroxy group, which may be etherified or esterified. The compounds of the invention have progestational and cortical activity.</p> |
