HUMAN MONOCLONAL ANTIBODIES TO CANCER CELLS

摘要

Hybridomas which produce human monoclonal antibodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a myeloma, from e.g., a human cell line, or a mouse cell line. The human monoclonal antibodies produced by these hybridomas recognize certain cell surface and intracellular antigens on normal and malignant cells. These human monoclonal antibodies are used in the diagnosis of cancer.