CHROMOGENIC COMPOUNDS,PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF AS ENZYME SUBSTRATES

摘要

Compounds of the formula II …… in which… R<1> represents an amino acid radical or the radical of an oligopeptide in which amino groups are optionally substituted by protective groups,… R<2> and R<3> are identical or different and denote hydrogen, or a lower alkyl, lower alkoxy, carboxyl, lower alkoxycarbonyl or an optionally lower alkyl-substituted carboxamido group or, if R<2> and R<3> are adjacent, represent a -CH=CH-CH=CH- group,… Z denotes a cross-conjugated positively charged bicyclic heterocyclic system and… X denotes an anion of an organic or inorganic acid. …These compounds are particularly suitable as chromogenic substrates for determining the activity of enzymes which cleave peptide bonds.