| 摘要 |
In the presence of a preserving additive, unilamellar phospholipid vesicle preparations are preserved during dehydration so that they can be stored for extended periods of time and aggregation or fusion of the vesicles is avoided without sacrifice of the utility of the vesicles or leakage of any enclosed material. The preserving additive is a carbohydrate, disaccharide, alcohol, protein, gum arabic or monosaccharide. Dehydration is effected by subjecting the preparations to a drying operation capable of causing flash evaporation. The vesicles upon reconstitution may have therapeutic and/or diagnostic agents incorporated in their internal aqueous cavities. |
