RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE

摘要

The present invention provides novel renin-inhibiting peptides having non-cleavable transition state inserts corresponding to the 10,11-position of a renin substrate (angiotensinogen) and having at least one cyclopropyl amino acid in place of an amino acid residue corresponding to position 6, 8, 9, 12, 13 or 14 of the renin substrate; and/or a cycloalkyl amino acid non-cleavable transition state insert in place of an amino acid residue corresponding to position 10 and 11 of the renin substrate. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension and other related deseases.