Thiazole derivatives active on the cholinergic system, process for their preparation and pharmaceutical compositions containing them.

摘要

New derivatives corresponding to the general formula <IMAGE> in which: - each of R1 and R2 independently denotes hydrogen; a C1-C4 alkyl group; a phenyl group; a phenyl group substituted once or more times by a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a nitro group or a hydroxyl group; or one of the groups R1 and R2 denotes hydrogen and the other denotes: a naphthyl group; a benzyl group; an alpha , alpha -dimethylbenzyl group; a cyclohexyl group; a biphenyl group; a thienyl group; an adamantyl group, or else R1 and R2 taken together denote a group: <IMAGE> where the phenyl group is bonded in position 4 of the thiazole and the (CH2)m group in position 5 and in which m denotes an integer equal to 2 or 3 and R5 denotes hydrogen or a nitro group occupying one of the free positions of the ring, - R3 denotes hydrogen or a C1-C4 alkyl group, - R4 denotes especially an alkyl substituted by an amino, pyrrolidino or pyridino group.