FREMGANGSMAADE TIL FREMSTILLING AF 2-(AZETIDIN-2-ON-1-YL)-2-OXOEDDIKESYREESTER-FORBINDELSER OG 2-(AZETIDIN-2-ON-1-YL)-2-HYDROXYEDDIKESYREESTER-FORBINDELSER TIL ANVENDELSE SOM UDGANGSMATERIALER VED FREMGANGSMAADEN

摘要

A process for production of a 2-azetidinone-1-oxoacetate of the formula useful as an intermediate for preparation of 2-SR<2>-substituted-2-penem-3-carboxylate antibacterial agents; R<1> is a conventional hydroxy protecting group, R<1> is certain carboxy protecting groups and R<2> is (C1-C6)alkyl, and m and n are each 0, 1 or 2; which comprises contacting a corresponding (2-oxo-1-azetidinyl)-N-2-hydroxyacetate ester of the formula with manganese dioxide in a reaction-inert organic solvent at 0-50 DEG C.