| 摘要 |
NEW MATERIAL:The compound of formula I [R is cyano, N,N-di(lower alkyl) aminocarbonyl or phenyl]. EXAMPLE:beta-(1-Adamantoyl)acrylonitrile. USE:A synthetic intermediate for compounds having various physiological activities. For example, the compound can be converted to a compound having anti- inflammatory action or herbicidal action. PREPARATION:The compound of formula I can be produced by reacting a 1-adamantanecarboxylic acid halide of formula II (X is halogen) with olefins of formula CH2=CH-R in the presence of a palladium catalyst and a tertiary amine. The reaction is carried out preferably in a solvent such as xylene at 100-150 deg.C. The amounts of olefins and catalyst are 1-10 equivalent and 0.1-5mol.% based on the compound of formula I, respectively.
|
