| 摘要 |
Novel 3-(2-haloalkyl)-1,4-oxathiins or 2-(2-haloalkyl)-1,4-dithiins, useful for regressing or inhibiting the growth of leukemia and tumors in mammals. The compounds have the formula.: <IMAGE> wherein R1 is an alkyl group containing up to 4 carbon atoms, cyclohexyl or phenyl; R2 is hydrogen or ethyl; R3 and R4 are each hydrogen, methyl or ethyl, and when either R3 and R4 is methyl or ethyl, the other is hydrogen; X is halogen; and Y is oxygen or sulfur and when Y is sulfur, R3 and R4 are both hydrogen. and pharmaceutical compositions comprising said compounds in admixture with a pharmaceutically acceptable substantially non-toxic carrier. |
