发明名称 |
Nontoxic pseudomonas aeruginosa polysaccharide-tetanus toxoid and polysaccharide-toxin a conjugate vaccines |
摘要 |
Polysaccharide-protein conjugates were synthesized utilizing polysaccharide derived from hydrolyized Pseudomonas aeruginosa lipopolysacharide covalently coupled to either tetanus toxoid or P. aeruginosa toxin A, utilizing a spacer molecule and a coupling agent. Conjugates produced in such a manner possess a molecular weight of greater than 350,000, are nontoxic and non-pyrogenic, and upon immunization of animals induced protective anti-LPS antibody and antibody which neutralizes the lethal effect of tetanus toxin or toxin A. The polysaccharide-tetanus toxoid conjugate and polysaccharide-toxin A conjugate are safe and immunogenic when parenterally administered to humans.
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申请公布号 |
US4771127(A) |
申请公布日期 |
1988.09.13 |
申请号 |
US19860892846 |
申请日期 |
1986.08.04 |
申请人 |
SWISS SERUM & VACCINE INSTITUTE BERNE |
发明人 |
CRYZ, STANLEY J.;FURER, EMIL P. |
分类号 |
A61K39/05;A61K39/08;A61K39/104;A61K39/108;A61K39/116;A61K39/385;A61K39/40;C07K16/12;(IPC1-7):C07K17/00 |
主分类号 |
A61K39/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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