PROCESS FOR THE PREPARATION OF CARBOXYLIC ACID AMIDES

摘要

Carboxylate amides of formula (I), its optically active antipode and physiologically acceptable salts are prepd. by reacting amine (II), its tautomer or its Li or Mg-halogenide-complex with carboxylic acid (III) or its reactive derivs.. R1 and R2=C1-4 dialkyl amino or N=alkyl-cyclohexylamino gp. with its attaching N atom, R3=H, halogen, Me, OH, aminosulfonyl, R4=H or Me, R5=H, Cl or Me, A=opt. substd. methylene by Me, Et or Ph, ethylene or vinylidene, B=methylene or ethylene, W=Me, CN, nitro or hydroxymethyl. (I) are useful for the treatment of diabetes.