| 摘要 |
PURPOSE:To obtain a remedy or prophylactic for ischemic heart diseases which contains + or --4-(4-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2h)-phtha lazinone or its salt as an active ingredient. CONSTITUTION:The objective remedy or prophylactic is obtained by using the compound of the formula or its salt as an active ingredient and customary carriers for medicament preparation and making pharmaceutical preparations in a usual manner. The compound can be made into injection solution, suppository, external preparation, instillation solution and other parenteral preparations and powder, capsules, syrup and other oral preparations. The composition is preferably served in the form suitable for enteric absorption. The dose is 0.01-200mg/adult/day and given in portions. The compound of the formula inhibits leukocytes from infiltrating into the ischemic parts in cardiac muscles to suppress the necrosis of the ischemic cardiac muscles.
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