发明名称 |
OPTISK AKTIVE OXO-ISOINDOLINYL DERIVATER |
摘要 |
Optically active oxo-isoindolinyl compounds of formula (I> <IMAGE> wherein R is C1-C4 alkyl; and R1 is hydrogen, C1-C4 alkyl or <IMAGE> wherein n is 1 or 2 and each of R2 and R3, which may be the same or different, is hydrogen or C1-C4 alkyl, or physiologically acceptable salts thereof, are prepared by resolving a racemic compound of formula (II): <IMAGE> into its optical isomers, to give an optically active compound of formula (II) as such or as a salt; reacting the said compound or salt with o-phthalic anhydride to give the corresponding optically active phthalimido compound; and reducing the optically active phthalimido compound. The product obtained can be esterified or salified as desired. The resultant optically active compounds, in particular that in which R is ethyl, exhibit platelet aggregation inhibiting activity. |
申请公布号 |
DK128988(A) |
申请公布日期 |
1988.09.11 |
申请号 |
DK19880001289 |
申请日期 |
1988.03.09 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
CARNIEL, GIOVANNI;ORZI, FABRIZIO;CERONI, GIORGIO;MIORINI, BRUNO;GRIGGI, PIERLUIGI |
分类号 |
C07D209/46;A61K31/40;A61K31/403;A61K31/4035;A61P7/02;A61P9/00;A61P25/04;A61P29/00;C07B53/00;(IPC1-7):C07D209/46;C07D209/48 |
主分类号 |
C07D209/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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