| 摘要 |
PURPOSE:To obtain a skin drug for external use, containing a specific amide derivative, capable of enhancing moisture holding power of keratinous layers and exhibiting excellent improving and preventive effects on roughening of the skin. CONSTITUTION:A skin drug for external use obtained by containing a compound expressed by formula I (R<1> is 10-26C hydrocarbon group; R<2> is 9-25C hydrocar bon group; n is 3-6), e.g. N-(2-hydroxyl-3-hexadecyloxypropyl)-N-3-hydroxy propylhexadacanamide, in an amount of 0.001-50wt.%, preferably 0.1-20wt.% based on the total composition. Effects are further increased by additionally blending 0.01-20wt.% preferably 0.1-5wt.% surfactant, particularly nonionic surfactant. The compound expressed by formula I is prepared by reacting a glycidyl ether expressed by formula II with an amino-alcohol expressed by formula III and then selectively acylating the amino group of the resultant compound expressed by formula IV. |
