| 摘要 |
NEW MATERIAL:The fluorine-containing pyrimidine derivative of formula I [R<1> is 1-5C alkyl, 3-6C cycloalkyl, benzyl which may be substituted with methyl, ethyl or Cl, phenyl which may be substituted with methyl, methoxy or Cl, -OR<4> or group of formula II (R<4>, R<5> and R<6> are H or lower alkyl); R<2> is halogen or amino which may be substituted with lower alkoxy, lower alkylthio or lower alkyl; R<3> is halogen, hydroxyl, group of formula III or formula IV; X is lower alkyl]. EXAMPLE:6-Fluoro-2-methyl-5-trifluoromethyl-4-pyrimidone. USE:Useful as pharmaceuticals such as carcinostatic agent or agricultural chemicals such as herbicide and insecticide and their synthetic intermediates. PREPARATION:The compound of formula I can be produced e.g. by reacting a compound of formula V (R is H, etc.) with a compound of formula VI (R<7> is 1-5C alkyl, etc.; X is halogen, etc.).
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